Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Post-Transplant Events

Significant loss of hepatitis A Ab after allogeneic hematopoietic SCT in pediatric patients

Bone Marrow Transplantation volume 45, pages 171–175 (2010)Cite this article

Abstract

Loss of specific immunity after hematopoietic SCT (HSCT) is well documented for polio, measles, mumps and tetanus. There are limited studies reporting the loss of Hepatitis A virus immunity and no reports evaluating the effect of donor immunity on Hepatitis A virus (HAV) immunity loss after HSCT. A total of 49 of the 81 patients who received HSCT at the Ankara University Pediatric HSCT Unit from January 1997 to December 2006 had HAV serology tested before HSCT and were evaluated for seroprevalence, and 30 of 49 patients were evaluated for the loss of Ab and for the effect of donor immunity on the loss of HAV Abs. The seroprevalence before HSCT was 75.5%. Loss of Ab was detected in 43.5% (10/23) of the patients. The median time to loss of Ab was 12 months (12–32 months), and 60% of these patients were seronegative at 12 months after HSCT. After HSCT, 46.7% of the patients were seronegative. Loss of Ab was higher in the seronegative donor group (75 vs 26%). The loss of HAV Ab is high after allogeneic HSCT for pediatric patients. Reimmunization should be considered for the continuation of individual and community immunity. Further studies with larger study groups are warranted to clarify the role of donor immunity on the loss of HAV immunity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ljungman P, Fridell E, Lönnqvist B, Bolme P, Böttiger M, Gahrton G et al. Efficacy and safety of vaccination of marrow transplant recipients with a live attenuated measles, mumps, and rubella vaccine. J Infect Dis 1989; 159: 610–615.

    Article  CAS  PubMed  Google Scholar 

  2. Spoulou V, Giannaki M, Vounatsou M, Bakoula C, Grafakos S . Long-term immunity to measles, mumps and rubella after MMR vaccination among children with bone marrow transplants. Bone Marrow Transplant 2004; 33: 1187–1190.

    Article  CAS  PubMed  Google Scholar 

  3. Ljungman P, Duraj V, Magnius L . Response to immunization against polio after allogeneic marrow transplantation. Bone Marrow Transplant 1991; 7: 89–93.

    CAS  PubMed  Google Scholar 

  4. Pauksen K, Hammarström V, Ljungman P, Sjölin J, Oberg G, Lönnerholm G et al. Immunity to poliovirus and immunization with inactivated poliovirus vaccine after autologous bone marrow transplantation. Clin Infect Dis 1994; 18: 547–552.

    Article  CAS  PubMed  Google Scholar 

  5. Ljungman P, Wiklund-Hammarsten M, Duraj V, Hammarström L, Lönnqvist B, Paulin T et al. Response to tetanus toxoid immunization after allogeneic bone marrow transplantation. J Infect Dis 1990; 162: 496–500.

    Article  CAS  PubMed  Google Scholar 

  6. Parkkali T, Stenvik M, Ruutu T, Hovi T, Volin L, Ruutu P . Randomized comparison of early and late vaccination with inactivated poliovirus vaccine after allogeneic BMT. Bone Marrow Transplant 1997; 20: 663–668.

    Article  CAS  PubMed  Google Scholar 

  7. Godoi ER, de Souza VA, Cakmak S, Machado AF, Vilas Boas LS, Machado CM . Loss of hepatitis A virus antibodies after bone marrow transplantation. Bone Marrow Transplant 2006; 38: 37–40.

    Article  CAS  PubMed  Google Scholar 

  8. Dignani MC, Miceli MH, Rosa CM, Gatica J, Martínez-Rolón J, Pizzolato M . Loss of hepatitis A virus (HAV) antibodies after peripheral stem cell transplantation (PSCT). Bone Marrow Transplant 2003; 31: 809–812.

    Article  CAS  PubMed  Google Scholar 

  9. Debray D, Cullufi P, Devictor D, Fabre M, Bernard O . Liver failure in children with hepatitis A. Hepatology 1997; 26: 1018–1022.

    Article  CAS  PubMed  Google Scholar 

  10. Sidal M, Unüvar E, O∂uz F, Cihan C, Onel D, Badur S . Age-specific seroepidemiology of hepatitis A, B, and E infections among children in Istanbul, Turkey. Eur J Epidemiol 2001; 17: 141–144.

    Article  CAS  PubMed  Google Scholar 

  11. Ungan M, Yaman H, Taheri N . The seroprevalence of specific antibodies to hepatitis A virus in a Turkish population. Eur J Gastroenterol Hepatol 2002; 14: 1033–1034.

    Article  PubMed  Google Scholar 

  12. Brinkman DM, Jol-van der Zijde CM, ten Dam MM, te Boekhorst PA, ten Cate R, Wulffraat NM et al. Resetting the adaptive immune system after autologous stem cell transplantation: lessons from responses to vaccines. J Clin Immunol 2007; 27: 647–658.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Parkkali T, Käyhty H, Hovi T, Olander RM, Roivainen M, Volin L et al. A randomized study on donor immunization with tetanus-diphtheria, Haemophilus influenzae type b and inactivated poliovirus vaccines to improve the recipient responses to the same vaccines after allogeneic bone marrow transplantation. Bone Marrow Transplant 2007; 39: 179–188.

    Article  CAS  PubMed  Google Scholar 

  14. Idilman R, Ustün C, Karayalçin S, Aktemel A, Turkyilmaz AR, Ozcan M et al. Hepatitis B virus vaccination of recipients and donors of allogeneic peripheral blood stem cell transplantation. Clin Transplant 2003; 17: 438–443.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Hematology, Ankara University, Ankara, Turkey

    E Unal Ince, M Ertem, T İleri, A Sayili, T Belgemen & Z Uysal

Authors
  1. E Unal Ince
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Ertem
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T İleri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Sayili
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T Belgemen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Z Uysal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Unal Ince.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Unal Ince, E., Ertem, M., İleri, T. et al. Significant loss of hepatitis A Ab after allogeneic hematopoietic SCT in pediatric patients. Bone Marrow Transplant 45, 171–175 (2010). https://doi.org/10.1038/bmt.2009.110

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2009.110

Keywords

Search

Advanced search

Quick links