Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Experimental Oncology
  • Published:

Detection of chromosomal 7 loss in myelodysplasia using an extremely polymorphic DNA probe

British Journal of Cancer volume 57, pages 131–134 (1988)Cite this article

Abstract

Chromosomal loss is a characteristic feature of the myelodysplastic syndromes (MDS). A method is described which detects chromosomal 7 loss in MDS by DNA analysis using a specific hypervariable region gene probe which has been cloned from a human DNA fingerprint. Loss of one of the chromosomal 7 homologues was demonstrated in 10/118 MDS patients; the ten patients include all the five patients which had previously been shown to have monosomy 7 by cytogenetic analysis. This technique makes it feasible to study serial samples from large numbers of patients for loss of chromosomal material and could be readily applied to the study of other human malignancies.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK

    SL Thein

Authors
  1. SL Thein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. DG Oscier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. AJ Jeffreys
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C Hesketh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Pilkington
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Summers
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Fitchett
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. JS Wainscoat
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thein, S., Oscier, D., Jeffreys, A. et al. Detection of chromosomal 7 loss in myelodysplasia using an extremely polymorphic DNA probe. Br J Cancer 57, 131–134 (1988). https://doi.org/10.1038/bjc.1988.27

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/bjc.1988.27

This article is cited by

Search

Advanced search

Quick links