Abstract
Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue.
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Raleigh, J., Miller, G., Franko, A. et al. Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours. Br J Cancer 56, 395–400 (1987). https://doi.org/10.1038/bjc.1987.213
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DOI: https://doi.org/10.1038/bjc.1987.213
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