Abstract
Activities of N-acetyl-β-D-glucosaminidase, N-acetyl-β-D-galactosaminidase, β-D-galactosidase and α-L-fucosidase were measured in rat colonic tumours induced by 1,2-dimethylhydrazine. Tumours varied considerably in their enzyme content, not only from different animals but also from the same animals. Enzymatic heterogeneity among tumours appeared to be related to their site of origin in the colon. The descending colon, which after the DMH treatment showed a significant increase in the levels of glycosidases, also gave rise to a larger number of adenocarcinomata than other parts of the colon. The relative changes in the activities of four glycosidases seemed to show a good correlation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Mian, N., Cowen, D. & Nutman, C. Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours. Br J Cancer 30, 231–237 (1974). https://doi.org/10.1038/bjc.1974.186
Issue Date:
DOI: https://doi.org/10.1038/bjc.1974.186
This article is cited by
-
Cancer of the large intestine in man: Progress and problems
La Ricerca in Clinica e in Laboratorio (1976)