Abstract
This study was conducted to induce chronic spinal cord compression myelopathy in rabbits. The L5 lumbar lamina was cut partially in 70 rabbits, and bone morphogenetic protein (BMP) was implanted on the ligamentum flavum in 35 of them. In the BMP group, new bone formed on the dorsal side of the spinal canal and flattened the spinal cord in an anteroposterior direction. No pathological changes were detected in the intramedullary tissues by light microscopic examination. In rabbits it is possible to induce compression of the cord by using BMP, although sufficient cord compression to induce myelopathy was not achieved.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mimatsu, K., Kishi, S. & Hashizume, Y. Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein. Spinal Cord 35, 740–746 (1997). https://doi.org/10.1038/sj.sc.3100533
Issue Date:
DOI: https://doi.org/10.1038/sj.sc.3100533
Keywords
This article is cited by
-
Hormones and growth factors in the pathogenesis of spinal ligament ossification
European Spine Journal (2007)
-
Dose-dependent effects of combined IGF-I and TGF-β1 application in a sheep cervical spine fusion model
European Spine Journal (2003)