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Coding SNPs included in exon arrays for the study of psychiatric disorders

Molecular Psychiatry volume 13, pages 363–365 (2008)Cite this article

Psychiatric disorders are thought to be multifactorial complex traits with partial predisposition driven by genetic variation altering expression or protein function. While genetic variants have been linked to certain psychiatric conditions and gene expression approaches have identified expression alterations, few studies have combined genetic and expression alterations in neuropsychiatric conditions.

Exon arrays have been proposed for the study of gene- and exon-level expression alterations, such as alternative splicing alterations. For this purpose, the Affymetrix Human Exon 1.0 ST array, containing over 5.5 million probes regrouped into 1.4 million probe sets, can be used to interrogate expression of the entire human transcriptome at the individual exon level. Here, we propose a method to use exon arrays also for the study of genetic variation in coding exons taking advantage of the presence of a large number of probes in regions of the transcriptome that contain single nucleotide polymorphisms (SNPs) (1.99 million SNPs in more than 5.5 million total probes).

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Authors and Affiliations

  1. Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA

    A Sequeira, B Rollins, W E Bunney & M P Vawter

  2. Departments of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA

    F Meng, S J Watson & H Akil

  3. Department of Genetics, Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA

    R M Myers

  4. Department of Psychiatry, Center for Neuroscience, University of California, Davis, CA, USA

    E G Jones

  5. Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA

    A F Schatzberg

  6. Department of Psychiatry, Cornell University, New York, NY, USA

    J Barchas

Authors
  1. A Sequeira
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  2. F Meng
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  3. B Rollins
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  4. R M Myers
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  5. E G Jones
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  6. S J Watson
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  7. H Akil
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  8. A F Schatzberg
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  9. J Barchas
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  10. W E Bunney
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  11. M P Vawter
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Corresponding author

Correspondence to M P Vawter.

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Sequeira, A., Meng, F., Rollins, B. et al. Coding SNPs included in exon arrays for the study of psychiatric disorders. Mol Psychiatry 13, 363–365 (2008). https://doi.org/10.1038/sj.mp.4002123

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