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Impact of obesity on disease-specific health status after percutaneous coronary intervention in coronary disease patients

International Journal of Obesity volume 28, pages 1011–1017 (2004)Cite this article

Abstract

OBJECTIVE: Several investigators have focused on obesity as a specific risk factor for mortality in patients undergoing bypass surgery, but few have examined it as a risk factor among patients undergoing percutaneous coronary interventions (PCI). In addition, none have evaluated the impact of obesity on post-PCI quality of life or disease-specific health status. This study examined whether obesity is a risk factor for poor quality of life or diminished health status 12-months postprocedure among a large cohort of PCI patients.

RESEARCH METHODS AND PROCEDURES: A total of 1631 consecutive PCI patients were enrolled into the study and classified as underweight (BMI <20 kg/m2), normal weight range (BMI ≥20 and <25 kg/m2), overweight (BMI ≥25 and <30 kg/m2), class I obese (BMI ≥30 kg/m2), or class II and III obese (BMI ≥35 kg/m2). The 12-month postprocedure outcomes included need for repeat procedure, survival, quality of life and health status, assessed using the Seattle Angina Questionnaire (SAQ) and the Short Form-12.

RESULTS: Obese patients with and without a history of revascularization were significantly younger than overweight, normal weight range, or underweight patients at the time of PCI. However, obese patients demonstrated similar long-term recovery and improved disease-specific health status and quality of life when compared to patients in the normal weight range after PCI. In addition, mortality and risk for repeat procedure was similar to those patients in the normal weight range patients at 12-months postrevascularization. Underweight patients who had no previous history of revascularization reported lower quality of life (F=3.02; P=0.018) and poorer physical functioning (F=2.82; P=0.024) than other BMI groups.

CONCLUSION: Obese patients presenting for revascularization were younger when compared to patients in the normal weight range, regardless of previous history of revascularization. However, weight status was not a significant predictor of differences in long-term disease-specific health status, quality of life, repeat procedures, or survival. Underweight patients demonstrated less improvement in quality of life and physical functioning than other BMI groups.

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Acknowledgements

This study was supported partially by a grant awarded by the Searle Pharmaceutical entitled ‘Post-Revascularization and Recovery Study.’ Work on this manuscript was supported by grants from the Agency for Healthcare Research and Quality (AHRQ – 3RO1 HS011282-02S1) and the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK – 1RO1 DK064284-01).

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  1. Mid America Heart Institute and University of Missouri-Kansas City, MO, USA

    W S Carlos Poston, C Keith Haddock, M Conard & J A Spertus

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Correspondence to W S Carlos Poston.

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Carlos Poston, W., Haddock, C., Conard, M. et al. Impact of obesity on disease-specific health status after percutaneous coronary intervention in coronary disease patients. Int J Obes 28, 1011–1017 (2004). https://doi.org/10.1038/sj.ijo.0802703

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