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Polymorphisms in the interleukin 17F gene (IL17F) and asthma

Genes & Immunity volume 6, pages 236–241 (2005)Cite this article

Abstract

Interleukin17F (IL17F) is a regulatory cytokine for T-cell-mediated immune responses. The gene coding for IL17F (IL17F) is located on chromosome 6p, a genomic region linked to asthma and asthma-related phenotypes in multiple genome scans. IL17F is expressed in lung tissue, in bronchoalveolar lavage fluid from asthmatic subjects, and in activated CD4+ cells. We were thus interested in testing for association between single-nucleotide polymorphisms (SNPs) and haplotypes in IL17F and asthma. To characterize polymorphisms in IL17F, we sequenced this gene in a group of African Americans and a group of European Americans. A total of 50 SNPs (30 not previously reported in a public database (dbSNP build 118)) and two insertions/deletions were detected in IL17F; five of these polymorphisms were genotyped in participants of the Nurses' Health Study. We then tested for association between SNPs and haplotypes in IL17F and physician-diagnosed asthma in subjects with (cases) and without (control subjects) physician-diagnosed asthma. None of the SNPs or haplotypes tested in IL17F were associated with asthma. The polymorphisms identified in this study may be used in future studies of association between IL17F and phenotypes related to immune responses.

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Acknowledgements

This work was supported by Programs for Genomic Applications, Grant U01 HL66795: Innate Immunity in Heart, Lung and Blood Disease, from the National Heart, Lung and Blood Institute. Dr Ramsey is supported by the University of Manitoba, Department of Medicine and NIH/NHLBI Training Grant # 5 T32 HL07427. Dr Celedón is supported by Grant K01 HL04370-01A1 from the National Institutes of Health.

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Authors and Affiliations

  1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

    C D Ramsey, R Lazarus, C A Camargo Jr, S T Weiss & J C Celedón

  2. Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    C A Camargo Jr

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  1. C D Ramsey
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  2. R Lazarus
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  3. C A Camargo Jr
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  4. S T Weiss
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  5. J C Celedón
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Correspondence to J C Celedón.

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Ramsey, C., Lazarus, R., Camargo, C. et al. Polymorphisms in the interleukin 17F gene (IL17F) and asthma. Genes Immun 6, 236–241 (2005). https://doi.org/10.1038/sj.gene.6364170

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  • DOI: https://doi.org/10.1038/sj.gene.6364170

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