Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DEVELOPMENTAL MODELS

Mechanics-guided developmental fate patterning

Nature Materials volume 17, pages 571–572 (2018)Cite this article

Subjects

A micropatterned human pluripotent stem cell-based developmental model was utilized to demonstrate the role of biophysical cues such as cell size and cytoskeletal contractile forces in directing patterning of neuroepithelial and neural plate border cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Neuroectoderm patterning from cell colonies.

References

  1. Green, J. B. A. & Sharpe, J. Development 142, 1203–1211 (2015).

    Article  Google Scholar 

  2. Eiraku, M. et al. Nature 472, 51–56 (2011).

    Article  Google Scholar 

  3. Lancaster, M. A. et al. Nature 501, 373–379 (2012).

    Article  Google Scholar 

  4. Shao, Y. et al. Nat. Mater. 16, 419–425 (2016).

    Article  Google Scholar 

  5. Tewary, M. et al. Development 144, 4298–4312 (2017).

    Article  Google Scholar 

  6. Warmflash, A., Sorre, B., Etoc, F., Siggia, E. D. & Brivanlou, A. H. Nat. Methods 11, 847–854 (2014).

    Article  Google Scholar 

  7. Xue, X. et al. Nat. Mater. https://doi.org/10.1038/s41563-018-0082-9 (2018).

    Google Scholar 

  8. Watt, F. M., Jordan, P. W. & O’Neill, C. H. Proc. Natl Acad. Sci. USA 85, 5576–5580 (1988).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

    Mukul Tewary & Peter W. Zandstra

  2. School of Biomedical Engineering, and the Michael Smith Laboratories at the University of British Columbia, Vancouver, British Columbia, Canada

    Peter W. Zandstra

Authors
  1. Mukul Tewary
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter W. Zandstra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter W. Zandstra.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tewary, M., Zandstra, P.W. Mechanics-guided developmental fate patterning. Nature Mater 17, 571–572 (2018). https://doi.org/10.1038/s41563-018-0121-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41563-018-0121-6

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research