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Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease

The Original Article was published on 24 June 2019

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Fig. 1: Revisiting the influences of MA and AP with new data.

References

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Acknowledgements

We thank M.-A. Martí-Renom for allowing J.A.R. to repeat the equivalent of his PhD thesis work in two frantic months during his postdoc. This work was supported by Ministerio de Ciencia e Innovación, Spain (with project grants BFU2015-68649-P, BFU2016-77961-P and PGC2018-101927-B-I00, MINECO/AEI/FEDER, UE), the Spanish National Institute of Bioinformatics (PT17/0009/0020), Direcció General de Recerca, Generalitat de Catalunya (2017SGR702, 2017SGR880) and the “Unidad de Excelencia María de Maeztu”, funded by the MINECO (ref: MDM-2014-0370).

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All authors contributed arguments and helpful ideas for this response. J.A.R. and X.F. compiled and analysed all new data. X.F. and J.A.R. generated all new plots. J.A.R., E.B. and A.N. wrote the original reply letter. All authors revised and contributed to the final text.

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Correspondence to Elena Bosch or Arcadi Navarro.

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The authors have no competing interests to declare.

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Supplementary Information

Supplementary Methods and Supplementary Fig. 1.

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Supplementary Data Tables 1–5

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Rodríguez, J.A., Farré, X., Muntané, G. et al. Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease. Nat Ecol Evol 3, 994–995 (2019). https://doi.org/10.1038/s41559-019-0926-y

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