Two papers present strong evidence that the codon-anticodon interaction is poised on a tipping point so that, given a nudge, the tRNA can insert the wrong amino acid into the growing polypeptide chain, leading to translational fidelity loss.
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Acknowledgements
We thank C. Florentz and S. Kelley for helpful comments on human mitochondrial tRNAs.
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Schimmel, P., Guo, M. A tipping point for mistranslation and disease. Nat Struct Mol Biol 16, 348–349 (2009). https://doi.org/10.1038/nsmb0409-348
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DOI: https://doi.org/10.1038/nsmb0409-348
