HIV-1 avoids the immune detection of infected cells by preventing class I molecules of the major histocompatibility complex (MHC-I) bound to viral peptides from reaching the cell surface. A new structure shows how Nef turns MHC-I from a noncargo into a cargo for the clathrin adaptor AP-1, thus directing MHC-I to the lysosome instead of the plasma membrane.
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Hurley, J., Bonifacino, J. Nef-arious goings-on at the Golgi. Nat Struct Mol Biol 19, 661–662 (2012). https://doi.org/10.1038/nsmb.2304
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DOI: https://doi.org/10.1038/nsmb.2304
