A catalytic reaction occurring on a single gold nanoparticle can be monitored directly with surface plasmon spectroscopy.
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Gates, B. Individual nanoparticles in action. Nature Nanotech 3, 583–584 (2008). https://doi.org/10.1038/nnano.2008.295
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DOI: https://doi.org/10.1038/nnano.2008.295