A large study of impulsivity in 14-year-olds finds that substance use and ADHD symptoms are associated with different brain networks that inhibit motor responses. Genetic analysis implicates the noradrenergic system in activity levels in one of these networks, which is centered on the right frontal cortex.
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Helfinstein, S., Poldrack, R. The young and the reckless. Nat Neurosci 15, 803–805 (2012). https://doi.org/10.1038/nn.3116
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DOI: https://doi.org/10.1038/nn.3116