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Organ alchemy: producing insulin in the liver

Expressing pancreatic transcription factors in the liver drives the formation of insulin-producing cells and normalizes blood glucose levels in a mouse model of diabetes (pages 596–603).

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Figure 1: Conversion of liver cells to pancreatic cells.

Kimberly Homer

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Correspondence to Kenneth S. Polonsky.

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Polonsky, K., Bell, G. Organ alchemy: producing insulin in the liver. Nat Med 9, 504–505 (2003). https://doi.org/10.1038/nm0503-504

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