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Intolerant of glucose and gasping for oxygen

Nature Medicine volume 15, pages 247–249 (2009)Cite this article

Findings in knockout mice indicate that hypoxia-sensitive pathways modulate the glucose-sensing machinery of pancreatic beta cells. Conditions that mimic hypoxia severely impair glucose-stimulated insulin release.

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Figure 1: Glucose-stimulated insulin secretion from pancreatic beta cells is triggered by glycolytic and mitochondrial metabolism, resulting in the generation of ATP, KATP channel closure and Ca2+ entry.

Katie Vicari

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Authors and Affiliations

  1. Fiona M. Gribble is at the Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK. fmg23@cam.ac.uk,

    Fiona M Gribble

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  1. Fiona M Gribble
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Gribble, F. Intolerant of glucose and gasping for oxygen. Nat Med 15, 247–249 (2009). https://doi.org/10.1038/nm0309-247

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