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When the KChIPs are down

Nature Medicine volume 8, pages 18–19 (2002)Cite this article

Defects in the mechanisms responsible for maintaining the heart's rhythmic contractions can be fatal. The finding that a defect in a potassium-channel accessory protein can predispose mice to cardiac arrhythmia provides insights into the molecular basis of this group of diseases.

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Figure 1: Functional consequences of loss of KChIP2 in the mouse heart and explanation of the transmural gradient in Ito in the human heart.

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  1. Department of Internal Medicine University of Utah, Salt Lake city, Utah, USA

    Michael C. Sanguinetti

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  1. Michael C. Sanguinetti
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Sanguinetti, M. When the KChIPs are down. Nat Med 8, 18–19 (2002). https://doi.org/10.1038/nm0102-18

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