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CD8+ T cell responses: it's all downhill after their prime ...

Nature Immunology volume 3, pages 601–602 (2002)Cite this article

The resolution of an immune response was thought to coincide with the clearance of infection. However, the kinetics of CD8+ T cell decline may be programmed far before the antigen load lightens.

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Figure 1: CD8+ T cell responses.

References

  1. Kaech, S.M. & Ahmed, R. Nature Immunol. 2, 415–422 (2001).

    Article  CAS  Google Scholar 

  2. van Stipdonk, M.J., Lemmens, E. E. & Schoenberger, S.P. Nature Immunol. 2, 423–429 (2001).

    Article  CAS  Google Scholar 

  3. Badovinac, V.P., Porter, B.B. & Harty, J.T. Nature Immunol. 2, 619–626 (2002).

    Article  Google Scholar 

  4. Kaech, S.M., Wherry, E.J. & Ahmed, R. Nature Rev. Immunol. 2, 251–262 (2002).

    Article  CAS  Google Scholar 

  5. Bird, J.J. et al. Immunity 9, 229–237 (1998).

    Article  CAS  Google Scholar 

  6. Arch, R.H. & Thompson, C.B. Annu. Rev. Cell Dev. Biol. 15, 113–140 (1999).

    Article  CAS  Google Scholar 

  7. Derby, M.A., Snyder, J.T., Tse, R., Alexander-Miller, M.A. & Berzofsky, J.A. Eur. J. Immunol. 31, 2951–2959 (2001).

    Article  CAS  Google Scholar 

  8. Grayson, J.M., Zajac, A.J., Altman, J.D. & Ahmed, R. J. Immunol. 164, 3950–3954 (2000).

    Article  CAS  Google Scholar 

  9. Badovinac, V.P., Tvinnereim, A.R. & Harty, J.T. Science 290, 1354–1358 (2000).

    Article  CAS  Google Scholar 

  10. Ehl, S., Klenerman, P., Zinkernagel, R.M. & Bocharov, G. Cell Immunol. 189, 67–73 (1998).

    Article  CAS  Google Scholar 

  11. Zajac, A.J. et al. J. Exp. Med. 188, 2205–2213 (1998).

    Article  CAS  Google Scholar 

  12. Tan, L.C. et al. J. Immunol. 162, 1827–1835 (1999).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, 1100 Fairview Ave. N., PO Box 19028, Seattle, 98109, WA, USA

    Joseph N. Blattman, Laurence E. Cheng & Philip D. Greenberg

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  1. Joseph N. Blattman
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  2. Laurence E. Cheng
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  3. Philip D. Greenberg
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Blattman, J., Cheng, L. & Greenberg, P. CD8+ T cell responses: it's all downhill after their prime .... Nat Immunol 3, 601–602 (2002). https://doi.org/10.1038/ni0702-601

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