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HIV vaccine design and the neutralizing antibody problem

Nature Immunology volume 5, pages 233–236 (2004)Cite this article

Eliciting broadly neutralizing antibodies to human immunodeficiency virus could bring closer the goal of a successful AIDS vaccine. Here the International AIDS Vaccine Initiative Neutralizing Antibody Consortium discusses current approaches to overcome the problems faced.

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Figure 1: A model of the HIV-1 envelope spike showing the location of epitopes recognized by broadly neutralizing mAbs.

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Authors and Affiliations

  1. Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California, USA

    Dennis R Burton

  2. Division of Microbiology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA

    Ronald C Desrosiers

  3. Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Robert W Doms

  4. International AIDS Vaccine Initiative, New York, New York, USA

    Wayne C Koff

  5. Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, USA

    Peter D Kwong, Gary J Nabel & Richard T Wyatt

  6. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

    John P Moore

  7. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Joseph Sodroski

  8. Department of Molecular Biology and the Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California, USA

    Ian A Wilson

Authors
  1. Dennis R Burton
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  2. Ronald C Desrosiers
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  4. Wayne C Koff
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  5. Peter D Kwong
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  7. Gary J Nabel
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  8. Joseph Sodroski
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  9. Ian A Wilson
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  10. Richard T Wyatt
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Correspondence to Dennis R Burton or John P Moore.

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Burton, D., Desrosiers, R., Doms, R. et al. HIV vaccine design and the neutralizing antibody problem. Nat Immunol 5, 233–236 (2004). https://doi.org/10.1038/ni0304-233

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