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Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

Nature Immunology volume 11, pages 109–111 (2010)Cite this article

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CTLA-4 is a potent coinhibitory molecule that is critical for peripheral T cell tolerance. New data suggest that CTLA-4 exerts its critical immunoregulatory functions by controlling antigen-specific conventional T cells as well as regulatory T cells.

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Figure 1: CTLA-4 limits autoantigen-specific T cells at multiple checkpoints.

Katie Vicari

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Authors and Affiliations

  1. Alison M. Paterson and Arlene H. Sharpe are in the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.,

    Alison M Paterson & Arlene H Sharpe

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  1. Alison M Paterson
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  2. Arlene H Sharpe
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Correspondence to Arlene H Sharpe.

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Paterson, A., Sharpe, A. Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells. Nat Immunol 11, 109–111 (2010). https://doi.org/10.1038/ni0210-109

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