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Osteopontin-induced survival of T cells

Relapses and exacerbation of clinical symptoms are hallmarks of debilitating autoimmune diseases like multiple sclerosis. Osteopontin-induced survival of autoreactive T cells may be one mechanism underlying the clinical progression of autoimmune disease.

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Figure 1: Many biological functions of Opn produced in the CNS could exacerbate EAE.

Katie Ris

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Correspondence to Joan M Goverman.

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Stromnes, I., Goverman, J. Osteopontin-induced survival of T cells. Nat Immunol 8, 19–20 (2007). https://doi.org/10.1038/ni0107-19

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