Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized locus-specific epigenetic mechanisms to promote recombination of the locus encoding the immunoglobulin κ-chain (Igk) and κ-chain+ B cell development.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Mandal, M. et al. Nat. Immunl. 16, 1094–1103 (2015).
Bergman, Y. & Cedar, H. Semin. Immunol. 22, 323–329 (2010).
Schatz, D.G. & Ji, Y. Nat. Rev. Immunol. 11, 251–263 (2011).
Shih, H.Y. & Krangel, M.S. J. Immunol. 190, 4915–4921 (2013).
Shimazaki, N., Tsai, A.G. & Lieber, M.R. Mol. Cell 34, 535–544 (2009).
Matthews, A.G. et al. Nature 450, 1106–1110 (2007).
Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. & Desiderio, S. Immunity 27, 561–571 (2007).
Kwon, J., Imbalzano, A.N., Matthews, A. & Oettinger, M.A. Mol. Cell 2, 829–839 (1998).
Teng, G. et al. Cell 162, 751–765 (2015).
Jones, J. M. et al. Immunol. Lett. 136, 156–162 (2011).
Grazini, U. et al. Mol. Cell 37, 282–293 (2010).
Brownlee, P.M., Meisenberg, C. & Downs, J.A. DNA Repair (Amst.) 32, 127–133 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
C.H.B. is a consultant for Regeneron Pharmaceuticals.
Rights and permissions
About this article
Cite this article
Fisher, M., Bassing, C. To κ+ B or not to κ+ B. Nat Immunol 16, 1007–1009 (2015). https://doi.org/10.1038/ni.3277
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3277