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Learning Impairment from Maternal Salicylate Treatment in Rats

Nature New Biology volume 236, pages 211–212 (1972)Cite this article

Abstract

THE administration of large doses of salicylates to pregnant animals produces malformations of the central nervous system, internal organs, and skeleton1. In rats, minor abnormalities are observed to result from a single oral dose of 250 mg kg−1 at day 9 of gestation, with the severity and frequency of malformations increasing at higher doses. The period of maximal susceptibility has been shown to be on days 9 and 10 of gestation2. This study provides preliminary evidence that doses too low to yield gross central nervous system malformations can produce behavioural impairments in the offspring.

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References

  1. Kalter, H., Teratology of the Central Nervous System (University of Chicago Press, Chicago and London, 1968).

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  2. Kimmel, C., Wilson, J., and Schumacher, H., Teratology, 4, 15 (1971).

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  3. Butcher, R. E., Stutz, R. M., and Berry, H. K., Amer. J. Ment. Defic., 75, 755 (1971).

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  4. Wilson, J., in Teratology: Principles and Techniques (edit. by Wilson, J., and Warkany, J.), 262 (University of Chicago Press, Chicago, 1965).

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Author information

Authors and Affiliations

  1. Children's Hospital Research Foundation, Institute for Developmental Research, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45229

    RICHARD E. BUTCHER & CHARLES V. VORHEES

  2. Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45219

    CAROLE A. KIMMEL

Authors
  1. RICHARD E. BUTCHER
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  2. CHARLES V. VORHEES
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  3. CAROLE A. KIMMEL
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BUTCHER, R., VORHEES, C. & KIMMEL, C. Learning Impairment from Maternal Salicylate Treatment in Rats. Nature New Biology 236, 211–212 (1972). https://doi.org/10.1038/newbio236211a0

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  • DOI: https://doi.org/10.1038/newbio236211a0

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