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Effect of Prostaglandin E1 on Leukocyte Migration

Nature New Biology volume 234, pages 114–115 (1971)Cite this article

Abstract

THE acute inflammatory response following many types of tissue injury involves principally an increase in vascular permeability and the migration of leukocytes towards the inflammatory focus1. Although the complement system is known to be involved in the acute inflammatory response to allergic causes2,3, the nature of non-immunologically induced inflammation, however, is still rather obscure. We recently reported that prostaglandin E1 (PGE1) increased vascular permeability in rat skin and rat cremasteric muscle to a degree, and in a pattern, not unlike that produced by histamine or serotonin4.

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References

  1. Hersch, E. M., and Bodey, G. P., Ann. Rev. Med., 21, 105 (1970).

    Article  Google Scholar 

  2. Ratnoff, O. D., and Lepow, I. H., J. Exp. Med., 118, 681 (1963).

    Article  CAS  Google Scholar 

  3. Ward, P. A., Cochrane, C. G., and Muller-Eberhard, H. J., Immunology, 11, 141 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Kaley, G., and Weiner, R., in Prostaglandin Symposium of the Worcester Foundation for Experimental Biology (edit. by Ramwell, P. W., and Shaw, J. E.), 321 (Interscience, New York, 1968).

    Google Scholar 

  5. Boyden, S., J. Exp. Med., 115, 453 (1962).

    Article  CAS  Google Scholar 

  6. Keller, H. U., and Sorkin, E., Immunology, 9, 441 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Horton, E. W., Physiol. Rev., 49, 122 (1969).

    Article  CAS  Google Scholar 

  8. Scott, R. E., Blood, 35, 514 (1970).

    CAS  PubMed  Google Scholar 

  9. Bourne, H. R., Lehrer, R. I., Melmon, K. L., and Cline, M. J., J. Clin. Invest., 49, 11a (1970) (Abstract).

    Google Scholar 

  10. Konijn, T. M., van de Meene, J. G. C., Bonner, J. T., and Barkley, D. S., Proc. US Nat. Acad. Sci., 58, 1152 (1967).

    Article  CAS  Google Scholar 

  11. Willis, A. L., J. Pharm. Pharmacol., 21, 126 (1969).

    Article  CAS  Google Scholar 

  12. Piper, P. J., and Vane, J. R., Nature, 223, 29 (1969).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology, New York Medical College, New York City, New York, 10029

    GABOR KALEY & RICHARD WEINER

Authors
  1. GABOR KALEY
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  2. RICHARD WEINER
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KALEY, G., WEINER, R. Effect of Prostaglandin E1 on Leukocyte Migration. Nature New Biology 234, 114–115 (1971). https://doi.org/10.1038/newbio234114a0

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