The dynamics of a complex chemical reaction that occurs through a well-defined intermediate have been followed at the single-molecule level using a 'nanoreactor' set-up, revealing a primary hydrogen isotope effect that is invisible to ensemble experiments.
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References
Levine, R. D. Molecular Reaction Dynamics (Cambridge Univ. Press, 2005).
Silbey, R. J. Proc. Natl Acad. Sci. USA 104, 12595 (2007).
Moerner, W. E. Proc. Natl Acad. Sci. USA 104, 12596–12602 (2007).
Fernandez, J. M & Li, H. Science 303, 1674–1678 (2004).
Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I. & Bustamante, C. Science 292, 733–737 (2001).
Lu, S., Li, W.-W., Rotem, D., Mikhailova, E. & Bayley, H. Nature Chem. 2, 921–928 10.1038/nchem.821 (2010).
Luchian, T., Shin, S.-H. & Bayley, H. Angew. Chem. Int. Ed. 42, 1926–1929 (2003).
Shin, S.-H., Steffensen, M. B., Claridge T. D. W. & Bayley, H. Angew. Chem. Int. Ed. 46, 7412–7416 (2007).
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Garcia-Manyes, S. Caught in the act. Nature Chem 2, 905–906 (2010). https://doi.org/10.1038/nchem.882
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DOI: https://doi.org/10.1038/nchem.882
