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Pulling cells out of tumours

Nature Cell Biology volume 19, pages 147–149 (2017)Cite this article

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Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.

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Figure 1: Fibroblasts lead cancer cell invasion via cadherin-mediated junctions.
Figure 2: Cadherin-dependent fibroblast-led cancer invasion.

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  1. Andrew J. Ewald is in the Departments of Cell Biology and Oncology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, Maryland 21205, USA,

    Andrew J. Ewald

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  1. Andrew J. Ewald
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Correspondence to Andrew J. Ewald.

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Ewald, A. Pulling cells out of tumours. Nat Cell Biol 19, 147–149 (2017). https://doi.org/10.1038/ncb3484

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