The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.
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References
Srivastava, D. Cell 126, 1037–1048 (2006).
Fahed, A. C., Gelb, B. D., Seidman, J. G. & Seidman, C. E. Circ. Res. 112, 707–720 (2013).
Towbin, J. A., Lorts, A. & Jefferies, J. L. Lancet 386, 813–825 (2015).
D'Amato, G. et al. Nat. Cell Biol. 18, 7–20 (2016).
Merki, E. et al. Proc. Natl Acad. Sci. USA 102, 18455–18460 (2005).
Odiete, O., Hill, M. F. & Sawyer, D. B. Circ. Res. 111, 1376–1385 (2012).
Del Monte, G. et al. Circ. Res. 108, 824–836 (2011).
Garg, V. et al. Nature 437, 270–274 (2005).
De la Pompa, J. L. & Epstein, J. A. Dev. Cell 22, 244–254 (2012).
Theodoris, C. V. et al. Cell 160, 1072–1086 (2015).
Grego-Bessa, J. et al. Dev. Cell 12, 415–429 (2007).
Hofmann, J. J. et al. Development 139, 4449–4460 (2012).
Luxan, G. et al. Nat. Med. 19, 193–201 (2013).
Dursun, M. et al. Eur. J. Radiol. 74, 147–151 (2010).
Buckingham, M., Meilhac, S. & Zaffran, S. Nat. Rev. Genet. 6, 826–835 (2005).
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Gifford, C., Srivastava, D. Heart disease modelling adds a Notch to its belt. Nat Cell Biol 18, 3–5 (2016). https://doi.org/10.1038/ncb3294
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DOI: https://doi.org/10.1038/ncb3294
