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Huntingtin facilitates selective autophagy

Nature Cell Biology volume 17, pages 214–215 (2015)Cite this article

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Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.

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Figure 1: Huntingtin acts as a scaffold protein that regulates selective autophagy.

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Authors and Affiliations

  1. Moran Rawet-Slobodkin and Zvulun Elazar are in the Department of Biological Chemistry, Amir Gelman, The Weizmann Institute of Science, 76100 Rehovot, Israel,

    Amir Gelman, Moran Rawet-Slobodkin & Zvulun Elazar

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  1. Amir Gelman
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  2. Moran Rawet-Slobodkin
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  3. Zvulun Elazar
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Correspondence to Zvulun Elazar.

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Gelman, A., Rawet-Slobodkin, M. & Elazar, Z. Huntingtin facilitates selective autophagy. Nat Cell Biol 17, 214–215 (2015). https://doi.org/10.1038/ncb3125

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