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To cluster or not to cluster: FRETting over rafts

Nature Cell Biology volume 6, pages 180–181 (2004)Cite this article

Lipid rafts are thought to be important for signalling cascades by compartmentalizing signalling components in the membrane. This view has recently come under fire because the common method used for isolation of rafts — detergent extraction — is fraught with artefacts. A variety of techniques, including FRET, have been used recently to investigate rafts in their native environment in intact cells. Now, FRET analysis provides evidence that rafts may not have a role in T-cell activation after all.

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Figure 1: Lipid rafts and T-cell signalling.

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  1. the Laboratory of Immunogenetics, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rockville, 20852, MD, USA

    Susan K. Pierce

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  1. Susan K. Pierce
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Pierce, S. To cluster or not to cluster: FRETting over rafts. Nat Cell Biol 6, 180–181 (2004). https://doi.org/10.1038/ncb0304-180

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