Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ran out of the nucleus for apoptosis

Nature Cell Biology volume 11, pages 11–12 (2009)Cite this article

Induction of apoptosis causes active dissipation of the RanGTP gradient across an intact nuclear envelope by immobilizing RCC1, the guanine nucleotide exchange factor for RanGTPase, on chromatin. The subsequent reduction in nuclear trafficking prevents the movement of NF-κB into the nucleus, thereby allowing apoptosis to proceed.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Diagram showing how apoptotic stimuli target Ran and NF-κB.

References

  1. Chipuk, J. E. & Green, D. R. Cell Cycle 3, 429–431 (2004).

    Article  CAS  Google Scholar 

  2. Perkins, N. D. Trends Cell Biol. 14, 64–69 (2004).

    Article  CAS  Google Scholar 

  3. Yasuhara, N. et al. Genes Cells 2, 55–64 (1997).

    Article  CAS  Google Scholar 

  4. Uchida, S., et al. Mol. Cell Biol. 10, 577–584 (1990).

    Article  CAS  Google Scholar 

  5. Wong, C.-H., et al. Nature Cell Biol. 11, 36–45 (2009).

    Article  CAS  Google Scholar 

  6. Li, H., Wirtz, D. & Zheng, Y. J. Cell Biol. 160, 635–644 (2003).

    Article  CAS  Google Scholar 

  7. Li, H. Y. & Zheng, Y. Genes & Development 18, 512–527 (2004).

    Article  CAS  Google Scholar 

  8. Cheung, W. L. et al. Cell 113, 507–517 (2003).

    Article  CAS  Google Scholar 

  9. Woo, I. S. et al. Apoptosis 13, 1223–1231 (2008).

    Article  CAS  Google Scholar 

  10. Rastogi, S., Joshi, B., Fusaro, G. & Chellappan, S. J. Biol. Chem. 281, 2952–2959 (2006).

    Article  Google Scholar 

  11. Greiss, S., Hall, J., Ahmed, S. & Gartner, A. Genes Dev. 22, 2831–2842 (2008).

    Article  CAS  Google Scholar 

  12. Behrens, P., Brinkmann, U. & Wellmann, A. Apoptosis 8, 39–44 (2003).

    Article  CAS  Google Scholar 

  13. Tanaka, T., Ohkubo, S., Tatsuno, J. & Prives, C. Cell 130, 638–650 (2007).

    Article  CAS  Google Scholar 

  14. Moss, D. K., Wilde, A. & Lane, J. D. J. Cell Sci. doi10.1242/jcs.037259 (2008).

  15. Tietze, N. et al. Oligonucleotides 18, 161–174 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Andrew Wilde is in the Department of Molecular Genetics, University of Toronto, M5S 1A8 Toronto, ON, Canada. andrew.wilde@utoronto.ca,

    Andrew Wilde

  2. Yixian Zheng is in the Department of Embryology, Carnegie Institution for Science and Howard Hughes Medical Institute, Baltimore, Maryland 21218, USA.,

    Yixian Zheng

Authors
  1. Andrew Wilde
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yixian Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wilde, A., Zheng, Y. Ran out of the nucleus for apoptosis. Nat Cell Biol 11, 11–12 (2009). https://doi.org/10.1038/ncb0109-11

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0109-11

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing