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Sustainable cutaneous gene delivery

Nature Biotechnology volume 15, pages 1388–1391 (1997)Cite this article

Abstract

Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic correction of human genetic skin disease due to loss of therapeutic gene expression in regenerated epidermal tissue has highlighted this current limitation. In an effort to surmount this problem, we have generated gene delivery vectors that produce more durable gene delivery in human skin tissue in vivo

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Author information

Author notes

  1. Paul A. Khavari: e-mail: khavari@CMGM.stanford.edu.

Authors and Affiliations

  1. V.A. Palo Alto Health Care System, Palo Alto, CA, 94304

    Helen Deng & Qun Lin

  2. Departement of Dermatology, Stanford University School of Medicine, Stanford, CA, 94305

    Helen Deng & Qun Lin

Authors
  1. Helen Deng
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  2. Qun Lin
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  3. Paul A. Khavari
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Deng, H., Lin, Q. & Khavari, P. Sustainable cutaneous gene delivery. Nat Biotechnol 15, 1388–1391 (1997). https://doi.org/10.1038/nbt1297-1388

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