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Custom design of metabolism

Nature Biotechnology volume 22, pages 823–824 (2004)Cite this article

Two new approaches, RNA-enzyme fusions immobilized onto a surface and artificial RNA switches, could transform metabolic pathway engineering.

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Figure 1: Two approaches for gaining control of metabolism.

Bob Crimi

References

  1. Jung, G.Y. & Stephanopoulos, G. Science 304, 428–431 (2004).

    Article  PubMed  Google Scholar 

  2. Isaacs, F.J. et al. Nat. Biotechnol. 22, 841–847 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. Patnaik, R. & Liao, J.C. Appl. Environ. Microbiol. 60, 3903–3908 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. San, K.-Y. et al. Metab. Eng. 4, 182–192 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. Roberts, R.W. & Szostak, J.W. Proc. Natl. Acad. Sci. USA 94, 12297–12302 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Elowitz, M.B. & Leibler, S. Nature 403, 335–338 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Gardner, T.S., Cantor, C.R. & Collins, J.J. Nature 403, 339–342 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Farmer, W.R. & Liao, J.C. Nature Biotechnol. 18, 533–537 (2000).

    Article  CAS  Google Scholar 

  9. Bulter, T et al. Proc. Natl. Acad. Sci. USA 101, 2299–2304 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. You, L.C., Cox, R.S., Weiss, R. & Arnold, F.H. Nature 428, 868–871 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

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  1. Department of Chemical Engineering, University of California, Los Angeles, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, 90095, California, USA

    James C Liao

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  1. James C Liao
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Liao, J. Custom design of metabolism. Nat Biotechnol 22, 823–824 (2004). https://doi.org/10.1038/nbt0704-823

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