Nature 440, 528–534 (2006)
During editing to meet Nature’s limits on length, we removed a reference to an earlier paper1 reporting that the prolyl isomerase Pin1 promotes production of Alzheimer’s amyloid-β (Aβ) from β-cleaved amyloid precursor protein (APP). That paper reported that Pin1 did not bind to full-length APP, but rather to the phosphorylated Thr 668–Pro motif of the carboxy-terminal C99 fragment of APP; Aβ production in Pin1-knockout mice was reduced only from this fragment.
References
Akiyama, H., Shin, R. W., Uchida, C., Kitamoto, T. & Uchida, T. Prolyl isomerase Pin1 facilitates production of Alzheimer’s amyloid-β from β-cleaved amyloid precursor protein Biochem. Biophys. Res. Commun. 336, 521–529 (2005)
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The online version of the original article can be found at 10.1038/nature04543
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Pastorino, L., Sun, A., Lu, PJ. et al. Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production. Nature 446, 342 (2007). https://doi.org/10.1038/nature05606
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DOI: https://doi.org/10.1038/nature05606
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