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Ethanol-induced Adaptation of Alcohol Dehydrogenase Activity in Rat Brain

Nature New Biology volume 236, pages 138–140 (1972)Cite this article

Abstract

ALTHOUGH the presence of alcohol dehydrogenase (ADH) in cerebral tissue has been established1, a physiological role for such a brain ethanol-oxidizing system has been unclear. The brain may be more biochemically adaptive than was once thought2; thus, it seemed possible that brain ADH may be substrate-induced. We now report that significant elevations of brain ADH activity occur in alcohol-imbibing rats; no changes from control values were found in liver ADH, liver aldehyde dehydrogenase (AldDH), or brain AldDH activities.

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References

  1. Raskin, N. H., and Sokoloff, L., J. Neurochem., 17, 1677 (1970).

    Article  CAS  Google Scholar 

  2. Mcllwain, H., Nature, 226, 803 (1970).

    Article  Google Scholar 

  3. Dietrich, R. A., Biochem. Pharm., 15, 1911 (1966).

    Article  Google Scholar 

  4. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Biol. Chem., 193, 265 (1951).

    CAS  Google Scholar 

  5. Mendelson, J. H., New Engl. J. Med., 283, 24 (1970).

    Article  CAS  Google Scholar 

  6. Mendelson, J., Wexler, D., Leiderman, P. H., and Solomon, P., Quart. J. Stud. Alcohol, 18, 561 (1957).

    CAS  PubMed  Google Scholar 

  7. Friedman, P. J., and Cooper, J. R., J. Pharm. Exp. Ther., 129, 373 (1960).

    CAS  Google Scholar 

  8. Hitchcock, P., and Nelson, E. E., J. Pharm. Exp. Ther., 79, 286 (1943).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology, University of California School of Medicine, San Francisco, California, 94122

    NEIL H. RASKIN

  2. Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland, 20014

    LOUIS SOKOLOFF

Authors
  1. NEIL H. RASKIN
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  2. LOUIS SOKOLOFF
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RASKIN, N., SOKOLOFF, L. Ethanol-induced Adaptation of Alcohol Dehydrogenase Activity in Rat Brain. Nature New Biology 236, 138–140 (1972). https://doi.org/10.1038/newbio236138a0

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