An ATP-sensitive K+ channel in glucose-responsive neurons is shown to be required for the emergency response to severe glucose deprivation, but not necessarily for normal feeding.
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References
Mayer, J. N. Engl. J. Med. 249, 13–16 (1953).
Oomura, Y., Ono, T., Ooyama, H. & Wayner, M. J. Nature 222, 282–284 (1969).
Miki, T. et al. Nat. Neurosci. 4, 507–512 (2001).
Mizuno, Y. & Oomura, Y. Brain Res. 307, 109–116 (1984).
Levin, B. E. Brain Res. 874, 158–164 (2000).
Liss, B., Bruns, R. & Roeper, J. EMBO J. 18, 833–846 (1999).
Anand, B. K. & Brobeck, J. R. Yale J. Biol. Med. 24, 123–146 (1951).
Borg, W. P., Sherwin, R. S., During, M. J., Borg, M. A. & Shulman, G. I. Diabetes 44, 180–184 (1995).
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D. & Ashford, M. L. Nature 390, 521–525 (1997).
Dagogo-Jack, S. E., Craft, S. & Cryer, P. E. J. Clin. Invest. 91, 819–828 (1993).
Tkacs, N. C., Dunn-Meynell, A. A. & Levin, B. E. Diabetes 49, 820–826 (2000).
Dunn-Meynell, A. A., Rawson, N. E. & Levin, B. E. Brain Res. 814, 41–54 (1998).
Lynch, R. M., Tompkins, L. S., Brooks, H. L., Dunn-Meynell, A. A. & Levin, B. E. Diabetes 49, 693–700 (2000).
Ritter, S., Dinh, T. T. & Zhang, Y. Brain Res. 856, 37–47 (2000).
Adachi, A., Shimizu, N., Oomura, Y. & Kobashi, M. Neurosci. Lett. 46, 215–218 (1984).
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Levin, B., Dunn-Meynell, A. & Routh, V. Brain glucosensing and the KATP channel. Nat Neurosci 4, 459–460 (2001). https://doi.org/10.1038/87405
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DOI: https://doi.org/10.1038/87405
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