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Brain glucosensing and the KATP channel

An ATP-sensitive K+ channel in glucose-responsive neurons is shown to be required for the emergency response to severe glucose deprivation, but not necessarily for normal feeding.

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Figure 1: Proposed role of the ATP-sensitive K+ (KATP) channel on glucose-responsive (GR) neurons.

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Levin, B., Dunn-Meynell, A. & Routh, V. Brain glucosensing and the KATP channel. Nat Neurosci 4, 459–460 (2001). https://doi.org/10.1038/87405

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