Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in αCGRP-deficient mice

Nature Neuroscience volume 4, pages 357–358 (2001)Cite this article

Abstract

The neuropeptide αCGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of αCGRP remains unclear. Here we show that mice lacking αCGRP display an attenuated response to chemical pain and inflammation. Furthermore, αCGRP−/− mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of αCGRP to opiate withdrawal.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Analysis of chemical pain.
Figure 2: Analgesia tests.
Figure 3: Addiction analyses.

Similar content being viewed by others

References

  1. Rosenfeld, M. G., Amara, S. G. & Evans, R. M. Science 225, 1315–1320 (1984).

    Article  CAS  Google Scholar 

  2. Hughes, S. R. & Brain, S. D. Br. J. Pharmacol. 104, 738–742 (1991).

    Article  CAS  Google Scholar 

  3. Gibbins, I. L., Furness, J. B. & Costa, M. Cell Tissue Res. 248, 417–437 (1987).

    Article  CAS  Google Scholar 

  4. Morton, C. R. & Hutchison, W. D. Neuroscience 31, 807–815 (1989).

    Article  CAS  Google Scholar 

  5. Friese, N. et al. Regul. Pept. 70, 1–7 (1997).

    Article  CAS  Google Scholar 

  6. Huang, Y. H., Brodda-Jansen, G., Lundeberg, T. & Yu, L. C. Brain Res. 873, 54–59 (2000).

    Article  CAS  Google Scholar 

  7. Welch, S. P., Singha, A. K. & Dewey, W. L. J. Pharmacol. Exp. Ther. 251, 1–8 (1989).

    CAS  PubMed  Google Scholar 

  8. Menard, D. P., Van Rossum, D., Kar, S. & Quirion, R. Can. J. Physiol. Pharmacol. 73, 1089–1095 (1995).

    Article  CAS  Google Scholar 

  9. Hökfel, T. et al. Ann. NY Acad. Sci. 657, 119–134 (1992).

    Article  Google Scholar 

  10. Salmon, A. M. et al. Neuroreport 10, 849–854 (1999).

    Article  CAS  Google Scholar 

  11. Franco-Cereceda, A. et al. Peptides 8, 399–410 (1987).

    Article  CAS  Google Scholar 

  12. Marubio, L. M. et al. Nature 398, 805–810 (1999).

    Article  CAS  Google Scholar 

  13. Schulteis, G., Markou, A., Gold, L. H., Stinus, L. & Koob, G. F. J. Pharmacol. Exp. Ther. 271, 1391–1398 (1994).

    CAS  PubMed  Google Scholar 

  14. Damasio, A. R. Descartes' Error: Emotion, Reason, and the Human Brain (Avon, New York, 1995).

    Google Scholar 

  15. Murtra, P., Sheasby, A. M., Hunt, S. P. & De Felipe, C. Nature 405, 180–183 (2000).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the Collège de France, the Association Française Contre les Myopathies, the Ligue Nationale Contre le Cancer, EEC Biomed and Biotech Programs BMHICT-941060 and 960236, NIH DA-05274, the National Association for Research on Schizophrenia and Depression, and Glaxo Wellcome.

Author information

Author notes

  1. M. Imad Damaj

    Present address: Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, 23298, USA

  2. Lisa M. Marubio

    Present address: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA

Authors and Affiliations

  1. CNRS URA 2182, Neurobiologie Moléculaire, Institut Pasteur, 25 rue du Docteur Roux, Paris, 75724 Cedex 15, France

    Anne-Marie Salmon & Jean-Pierre Changeux

  2. Glaxo Wellcome Experimental Research, Institut de Biologie Cellulaire et de Morphologie, Université de Lausanne, rue du Bugnon 9, Lausanne, 1005, Switzerland

    Mark P. Epping-Jordan

  3. Glaxo Wellcome Medicine Research Centre, via Fleming 4, Verona, 37100, Italy

    Emilio Merlo-Pich

Authors
  1. Anne-Marie Salmon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Imad Damaj
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lisa M. Marubio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mark P. Epping-Jordan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Emilio Merlo-Pich
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jean-Pierre Changeux
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean-Pierre Changeux.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salmon, AM., Damaj, M., Marubio, L. et al. Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in αCGRP-deficient mice. Nat Neurosci 4, 357–358 (2001). https://doi.org/10.1038/86001

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/86001

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing