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Neuroligation: building synapses around the neurexin–neuroligin link

Nature Neuroscience volume 3, pages 747–749 (2000)Cite this article

Serafini and colleagues provide evidence that neuroligin acts as a trans-neuronal signal to induce presynaptic differentiation at neuron–neuron connections in vitro.

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Figure 1: Neuroligin induces presynaptic differentiation.
Figure 2: Model of neuroligin–β-neurexin function at glutamatergic synapses.

References

  1. Scheiffele, P., Fan, J., Choih, J., Fetter, R. & Serafini, T. Cell 101, 657– 669 (2000).

    Article  CAS  Google Scholar 

  2. Sanes, J. R. & Lichtman, J. W. Annu. Rev. Neurosci. 22, 389–442 (1999).

    Article  CAS  Google Scholar 

  3. Baird, D. H., Hatten, M. E. & Mason, C. A. J. Neurosci. 12, 619– 634 (1992).

    Article  CAS  Google Scholar 

  4. Missler, M., Fernandez-Chacon, R. & Sudhof, T. C. J. Neurochem. 71, 1339– 1347 (1998).

    Article  CAS  Google Scholar 

  5. Song, J. Y., Ichtchenko, K., Sudhof, T. C. & Brose, N. Proc. Natl. Acad. Sci. USA 96, 1100– 1105 (1999).

    Article  CAS  Google Scholar 

  6. Verderio, C., Coco, S., Pravettoni, E., Bacci, A. & Matteoli, M. Cell Mol. Life Sci. 55, 1448– 1462 (1999).

    Article  CAS  Google Scholar 

  7. Zakharenko, S., Chang, S., O'Donoghue, M. & Popov, S. V. J. Cell Biol. 144, 507–518 (1999).

    Article  CAS  Google Scholar 

  8. Ahmari, S. E., Buchanan, J. & Smith, S. J. Nat. Neurosci. 3, 445– 451 (2000).

    Article  CAS  Google Scholar 

  9. Hata, Y., Davletov, B., Petrenko, A. G., Jahn, R. & Sudhof, T. C. Neuron 10, 307–315 (1993).

    Article  CAS  Google Scholar 

  10. Hata, Y., Butz, S. & Sudhof, T. C. J. Neurosci. 16, 2488– 2494 (1996).

    Article  CAS  Google Scholar 

  11. Hsueh, Y. P. et al. J. Cell Biol. 142, 139– 151 (1998).

    Article  CAS  Google Scholar 

  12. Butz, S., Okamoto, M. & Sudhof, T. C. Cell 94, 773– 782 (1998).

    Article  CAS  Google Scholar 

  13. Setou, M., Nakagawa, T., Seog, D.-H. & Hirokawa, N. Science 288, 1796–1802 ( 2000).

    Article  CAS  Google Scholar 

  14. Hirao, K. et al. J. Biol. Chem. 273, 21105– 21110 (1998).

    Article  CAS  Google Scholar 

  15. Irie, M. et al. Science 277, 1511–1515 (1997).

    Article  CAS  Google Scholar 

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  1. Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, 63110, Missouri, USA

    Anuradha Rao, Kimberly J. Harms & Ann Marie Craig

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  1. Anuradha Rao
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  2. Kimberly J. Harms
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  3. Ann Marie Craig
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Rao, A., Harms, K. & Craig, A. Neuroligation: building synapses around the neurexin–neuroligin link. Nat Neurosci 3, 747–749 (2000). https://doi.org/10.1038/77636

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