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Keeping in touch with angiogenesis

Nature Medicine volume 6, pages 379–381 (2000)Cite this article

Ischemic peripheral neuropathy is a frequent, severe and irreversible complication of critical limb ischemia. Therapeutic angiogenesis may ameliorate vascular insufficiency and may also provide direct beneficial effects on neural integrity, indicating a new paradigm for the treatment of neuronal disorders (pages 405–413).

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Figure 1: The VEGF agonist–antagonist paradox.

Bob Crimi

References

  1. Eames,R.A. & Lange,L.S. Clinical and pathological study of ischaemic neuropathy. J. Neurol. Neurosurg. Psychiatry 30, 215–226 (1967).

    Article  CAS  Google Scholar 

  2. Schratzberger, et al. Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nature Med. 6, 405–413 ( 2000).

    Article  CAS  Google Scholar 

  3. Kornowski,R., Fuchs,S., Leon,M.B. & Epstein,S.E. Delivery strategies to achieve therapeutic myocardial angiogenesis. Circulation 101, 454–458 (2000).

    Article  CAS  Google Scholar 

  4. Leung,D.W., Cachianes,G., Kuang,W.J., Goeddel,D.V. & Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306– 1309 (1989).

    Article  CAS  Google Scholar 

  5. Senger,D.R. et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983–985 (1983).

    Article  CAS  Google Scholar 

  6. Shweiki,D., Itin,A., Soffer,D. & Keshet,E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis . Nature 359, 843–845 (1992).

    Article  CAS  Google Scholar 

  7. Losordo,D.W. et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 98, 2800 –2804 (1998).

    Article  CAS  Google Scholar 

  8. Baumgartner,I. et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia [see comments]. Circulation 97, 1114–1123 (1998).

    Article  CAS  Google Scholar 

  9. Aiello,L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480–1487 ( 1994).

    Article  CAS  Google Scholar 

  10. Casey,R. & Li,W.W. Factors controlling ocular angiogenesis . Am. J. Ophthalmol. 124, 521– 529 (1997).

    Article  CAS  Google Scholar 

  11. Duh,E. & Aiello,L.P. Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes 48, 1899–1906 (1999).

    Article  CAS  Google Scholar 

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  1. Assistant Professor of Ophthalmology Harvard Medical School Investigator, Joslin Diabetes Center One Joslin Place, Boston , 02215, Massachusetts

    Lloyd Paul Aiello

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  1. Lloyd Paul Aiello
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Aiello, L. Keeping in touch with angiogenesis. Nat Med 6, 379–381 (2000). https://doi.org/10.1038/74633

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