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Chemical biology

Greasy tags for protein removal

Nature volume 487, pages 308–309 (2012)Cite this article

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Most proteins in the human body are difficult targets for small-molecule drugs. This problem may have been overcome with the discovery of molecules that induce protein degradation, suggesting fresh, modular approaches to drug discovery.

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Figure 1: Hydrophobic tags for protein degradation.

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Authors and Affiliations

  1. Taavi K. Neklesa and Craig M. Crews are in the Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.,

    Taavi K. Neklesa & Craig M. Crews

  2. C.M.C. is also in the Departments of Chemistry and of Pharmacology, Yale University.,

    Craig M. Crews

Authors
  1. Taavi K. Neklesa
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  2. Craig M. Crews
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Correspondence to Craig M. Crews.

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Neklesa, T., Crews, C. Greasy tags for protein removal. Nature 487, 308–309 (2012). https://doi.org/10.1038/487308a

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