The biosynthesis of vitamin B12 has fascinated generations of scientists, but part of the pathway was unknown. The missing enzymatic link has now been found, only to raise more mechanistic questions.
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References
Taga, M. E., Larsen, N. A., Howard-Jones, A. R., Walsh, C. T. & Walker, G. C. Nature 446, 449–453 (2007).
Roessner, C. A., Santander, P. J. Vitam. Horm. 61, 267–297 (2001).
Renz, P. in Chemistry and Biochemistry of B12 (ed. Banerjee, R.) 557–575 (Wiley, Weinheim, 1999).
Berkovitch, F., Nicolet, Y., Wan, J. T., Jarrett, J. T. & Drennan, C. L. Science 303, 76–80 (2004).
Cicchillo, R. M. & Booker, S. J. J. Am. Chem. Soc. 127, 2860–2861 (2005).
Chatterjee, A., Jurgenson, C. T., Schroeder, F. C., Ealick, S. E. & Begley, T. P. J. Am. Chem. Soc. 128, 7158–7159 (2006).
Maggio-Hall, L. A., Dorrestein, P. C., Escalante-Semerena, J. C. & Begley, T. P. Org. Lett. 5, 2211–2213 (2003).
Hodgkin, D. C. et al. Proc. R. Soc. Lond. A 242, 228–263 (1957).
Eschenmoser, A. Angew. Chem. 100, 5–40 (1988).
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Ealick, S., Begley, T. Molecular cannibalism. Nature 446, 387–388 (2007). https://doi.org/10.1038/446387a
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DOI: https://doi.org/10.1038/446387a
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