As massive ice sheets grew on Antarctica during the first major glaciation of the Cenozoic era, the northern continents cooled and dried. The coincidence in timing implies that the cause was global rather than regional.
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Bowen, G. When the world turned cold. Nature 445, 607–608 (2007). https://doi.org/10.1038/445607a
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DOI: https://doi.org/10.1038/445607a
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