Autophagy — cellular ‘self-eating’ — can be induced by stress, but it also acts continuously in a housekeeping role, disposing of unwanted proteins. Can it protect against neurodegenerative diseases?
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism
Cellular & Molecular Biology Letters Open Access 02 March 2022
-
Impaired autophagic flux is associated with the severity of trauma and the role of A2AR in brain cells after traumatic brain injury
Cell Death & Disease Open Access 14 February 2018
-
Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death
Cell Death & Disease Open Access 08 January 2015
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rubinsztein, D. C. et al. Autophagy 1, 11–22 (2005).
Komatsu, M. et al. Nature 441, 880–884 (2006).
Hara, T. et al. Nature 441, 885–889 (2006).
Levine, B. & Klionsky, D. J. Dev. Cell 6, 463–477 (2004).
Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R. & Finkbeiner, S. Nature 431, 805–810 (2004).
Tanaka, M. et al. J. Biol. Chem. 279, 4625–4631 (2004).
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. Mol. Biol. Cell 15, 1101–1111 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klionsky, D. Good riddance to bad rubbish. Nature 441, 819–820 (2006). https://doi.org/10.1038/441819a
Published:
Issue Date:
DOI: https://doi.org/10.1038/441819a
This article is cited by
-
Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism
Cellular & Molecular Biology Letters (2022)
-
Impaired autophagic flux is associated with the severity of trauma and the role of A2AR in brain cells after traumatic brain injury
Cell Death & Disease (2018)
-
Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death
Cell Death & Disease (2015)
-
The role of autophagy in Parkinson's disease: rotenone-based modeling
Behavioral and Brain Functions (2013)
-
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
Molecular Neurodegeneration (2012)
