Glucose output from the liver is tightly regulated by insulin. But insulin holds sway over more than the liver — an unappreciated circuit in glucose control involves the opening of ion channels in the brain.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Nature Communications Open Access 27 February 2019
-
Changes in the liver transcriptome of farmed Atlantic salmon (Salmo salar) fed experimental diets based on terrestrial alternatives to fish meal and fish oil
BMC Genomics Open Access 03 November 2018
-
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
Nature Communications Open Access 06 October 2016
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pocai, A. et al. Nature 434, 1026–1031 (2005).
Schwartz, M. W. & Porte, D. Jr Science 307, 375–379 (2005).
Obici, S., Zhang, B. B., Karkanias, G. & Rossetti, L. Nature Med. 8, 1376–1382 (2002).
Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H. & Ashford, M. L. Nature Neurosci. 3, 757–758 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gribble, F. A higher power for insulin. Nature 434, 965–966 (2005). https://doi.org/10.1038/434965a
Published:
Issue Date:
DOI: https://doi.org/10.1038/434965a
This article is cited by
-
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Nature Communications (2019)
-
Changes in the liver transcriptome of farmed Atlantic salmon (Salmo salar) fed experimental diets based on terrestrial alternatives to fish meal and fish oil
BMC Genomics (2018)
-
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
Nature Communications (2016)
-
Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling
Nature Communications (2014)
-
Increasing prevalence of diabetes mellitus in association with fatty liver in a Japanese population
Journal of Gastroenterology (2014)
