Abstract
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.
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Powis, S., Deverson, E., Coadweil, W. et al. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature 357, 211–215 (1992). https://doi.org/10.1038/357211a0
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DOI: https://doi.org/10.1038/357211a0
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