Abstract
ANTERIOR–POSTERIOR patterning in insects, vertebrates and nematodes involves members of conserved Antennapedia-class homeobox gene clusters (HOM-C) that are thought to give specific body regions their identities1–5. The effects of these genes on region-specific body structures have been described extensively, particularly in Drosophila, but little is known about how HOM-C genes affect the behaviours of cells that migrate into their domains of function. In Caenorhabditis elegans, the Antennapedia-like HOM-C gene mab-5 not only specifies postembryonic fates of cells in a posterior body region, but also influences the migration of mesodermal and neural cells that move through this region5–7. Here we show that as one neuroblast migrates into this posterior region, it switches on mab-5 gene expression; mab-5 then acts as a developmental switch to control the migratory behaviour of the neuroblast descendants. HOM-C genes can therefore not only direct region-specific patterns of cell division and differentiation, but can also act within migrating cells to programme region-specific migratory behaviour.
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References
Gehring, W. J. Science 236, 1245–1252 (1987).
Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. & Krumlauf, R. Nature 341, 405–409 (1989).
Reid, L. Cell 63, 875–882 (1990).
Burglin, T. R. et al. Nature 351, 703 (1991).
Kenyon, C. & Wang, B. Science 253, 516–517 (1991).
Costa, M., Weir, M., Coulson, A., Sulston, J. & Kenyon, C. Cell 55, 747–756 (1988).
Kenyon, C. Cell 46, 477–487 (1986).
Chalfie, M. & Sulston, J. Devl. Biol. 82, 358–370 (1981).
White, J., Southgate, E., Thomson, J. & Brenner, S. Phil. Trans. R. Soc. 314B, 1–340 (1986).
Sulston, J. & Horvitz, H. Devl. Biol. 56, 110–156 (1977).
Chalfie, M. Thomson, J. & Sulston, J. Science 221, 61–63 (1983).
Hedgecock, E., Culotti, J., Hall, D. & Stern, B. Development 100, 365–382 (1987).
Frohman, M. A., Boyle, M. & Martin, G. R. Development 110, 589–607 (1990).
Hunt, P., Wilkinson, D. & Krumlauf, R. Development 112, 43–50 (1991).
Wolgemuth, D. J., Behringer, R. R., Mostoller, M. P., Brinster, R. L. & Palmiter, R. D. Nature 337, 464–467 (1989).
Cho, K. W. Y. et al. EMBO J. 7, 2139–2149 (1988).
Balling, R., Mutter, G., Gruss, P. & Kessel, M. Cell 58, 337–347 (1989).
Chisaka, O. & Capecchi, M. R. Nature 350, 473–479 (1991).
Damsky, C. H., Fitzgerald, M. L. & Fisher, S. J. J. clin. Invest. (in the press).
Klambt, C., Jacobs, J. R. & Goodman, C. S. Cell 64, 801–815 (1991).
Elkins, T., Zinn, K., McAllister, L., Hoffmann, F. M. & Goodman, C. S. Cell 60, 565–575 (1990).
Dodd, J. & Jessell, T. M. Science 242, 692–699 (1988).
Fire, A. EMBO J. 5, 2673–2680 (1986).
Mello, C., Kramer, J., Stinchcomb, D. & Ambros, V. EMBO J. (in the press).
Russnak, R. & Candido, E. P. M. Molec. cell. Biol. 5, 1268–1278 (1985).
Stringham, E. G., Dixon, D. K., Jones, D. & Candido, E. P. M. Molec. Biol. Cell. (in the press).
Fire, A., White-Harrison, S. & Dixon, D. Gene 93, 189–198 (1990).
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Salser, S., Kenyon, C. Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration. Nature 355, 255–258 (1992). https://doi.org/10.1038/355255a0
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DOI: https://doi.org/10.1038/355255a0
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