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Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

Nature volume 353, pages 822–827 (1991)Cite this article

Abstract

The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a represser of normal gene activity during heat stress.

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Authors and Affiliations

  1. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bg 37, Rm 4C-09, Bethesda, Maryland, 20892, USA

    J. Timothy Westwood, Joachim Clos & Carl Wu

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  2. Joachim Clos
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  3. Carl Wu
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Westwood, J., Clos, J. & Wu, C. Stress-induced oligomerization and chromosomal relocalization of heat-shock factor. Nature 353, 822–827 (1991). https://doi.org/10.1038/353822a0

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