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Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene

Nature volume 353, pages 351–353 (1991)Cite this article

Abstract

THE Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and bithorax (bx-C) complexes, and hence for the maintenance of segmental determination1–3. We report the predicted protein sequence of the Pc-G gene Posterior Sex Combs (Psc), and of the neighbouring and related gene Suppressor two of zeste (Su(z)2). Both genes encode large proteins that contain a 200 amino-acid domain identical over 37.4% that is also conserved in the murine oncogene bmi-1 (refs 4,5). At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger6.

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Author notes

  1. Brian P. Brunk

    Present address: Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania, 19111, USA

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  1. Biology Department, Molecular Biology Institute and Cancer Center, University of Virginia, Charlottesville, Virginia, 22901, USA

    Elisabeth C. Martin & Paul N. Adler

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  2. Elisabeth C. Martin
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  3. Paul N. Adler
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Brunk, B., Martin, E. & Adler, P. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Nature 353, 351–353 (1991). https://doi.org/10.1038/353351a0

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