Abstract
Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.
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References
Vogt, P. K. & Bos, T. J. Adv. Cancer Res. 55, 1–35 (1990).
Bos, T. J. et al. Genes Dev. 4, 1677–1687 (1990).
Schütte, J., Minna, J. & Birrer, M. Proc. natn. Acad. Sci. U.S.A. 86, 2257–2261 (1989).
Bohmann, D. et al. Science 238, 1386–1392 (1987).
Angel, P. et al. Nature 332, 166–171 (1988).
Angel, P. et al. Cell 49, 729–739 (1987).
Lee, W., Mitchell, P. J. & Tjian, R. Cell 49, 741–752 (1987).
Karin, M. in Molecular Aspects of Cellular Regulation (eds Cohen, P. & Foulkes, G.) 6, 143–161 (Elsevier/North-Holland Biomedical, Amsterdam, 1990).
Chiu, R., Angel, P. & Karin, M. Cell 59, 979–986 (1989).
Hirari, S. I., Ryseck, R. P., Mechta, F., Bravo, R. & Yaniv, M. EMBO J. 8, 1433–1439 (1989).
Yang-Yen, H.-F., Chiu, R. & Karin, M. New Biol. 2, 351–361 (1990).
Greenberg, M. E. & Ziff, E. B. Nature 311, 433–438 (1984).
Quantin, B. & Breathnach, R. Nature 334, 538–539 (1988).
Ryseck, R. P., Hirai, S. I., Yaniv, M. & Bravo, R. Nature 334, 535–537 (1988).
Lamph, W. W., Wamsley, P., Sassone-Corsi, P. & Verma, I. M. Nature 344, 629–631 (1988).
Angel, P., Hattori, K., Smeal, T. & Karin, M. Cell 55, 875–885 (1988).
Boyle, W. J. et al. Cell 64, 573–584 (1991).
Imler, J. L., Schatz, C., Wasylyk, C., Chatton, B. & Wasylyk, B. Nature 332, 275–278 (1988).
Piette, J., Hirai, S. I. & Yaniv, M. Proc. natn. Acad. Sci. U.S.A. 85, 3401–3405 (1988).
Wasylyk, C., Imler, J. L. & Wasylyk, B. EMBO J. 7, 2475–2483 (1988).
Schonthal, A., Herrlich, P., Rahmsdorf, H. J. & Ponta, H. Cell 54, 325–334 (1988).
Herrlich, P. & Ponta, H. Trend Genet. 5, 112–116 (1989).
Sistonen, L., Holtta, E., Makela, T. P., Keski-Oja, J. & Alitalo, K. EMBO J. 8, 815–822 (1989).
Stacey, D. W., Watson, T., Kung, H.-F. & Curran, T. Molec. cell. Biol. 7, 523–527 (1987).
Dotto, G. P., Parada, L. F. & Weinberg, R. A. Nature 318, 472–475 (1985).
Zarbl, H., Latrelle, J. & Jolicoeur, P. Cell 51, 357–369 (1987).
Wisdom, R. & Verma, I. M. Molec. cell. Biol. 10, 5626–5633 (1990).
Land, H. et al. Molec. cell. Biol. 6, 1917–1925 (1988).
Imler, J. L., Ugarte, E., Wasylyk, C. & Wasylyk, B. Nucleic Acids Res. 16, 3005–3012 (1988).
Baichwal, V. R. & Tjian, R. Cell 65, 815–823 (1990).
Angel, P., Smeal, T., Meek, J. & Karin, M. New Biol., 1, 35–43 (1989).
Jaggi, R., Salmons, B., Muellener, D. & Groner, B. EMBO J. 5, 2609–2616 (1986).
Jonat, C. et al. Cell 62, 1189–1204 (1990).
Yang-Yen, H.-F. et al. Cell 62, 1205–1215 (1990).
Lucibello, F. et al. EMBO J. 9, 2827–2834 (1990).
Chiu, R. et al. Cell 54, 541–552 (1988).
Smeal, T., Angel, P., Meek, J. & Karin, M. Genes Dev. 3, 2091–2100 (1989).
Theill, L., Castrillo, J.-L., Wu, D. & Karin, M. Nature 342, 945–948 (1989).
McCormick, A., Brady, H., Theill, L. E. & Karin, M. Nature 345, 829–832 (1990).
Weinberg, R. A. Cancer Res. 49, 3713–3721 (1989).
Ruley, H. E. Cancer Cells 2, 258–268 (1990).
Hunter, T. Cell 64, 249–270 (1991).
Gonzalez, G. A. & Montminy, M. R. Cell 59, 675–680 (1989).
Ofir, R., Dwarki, V. J., Rashid, D. & Verma, I. M. Nature 348, 78–80 (1990).
Schutte, J., et al. Cell 59, 987–997 (1989).
McCormick, F. in Oncogenes and the Molecular Origins of Cancer (ed. Weinberg, R. A.) 125–145 (Cold Spring Harbor Laboratory, New York, 1989).
Lacal, J. C., Fleming, P. T., Warren, B. S., Blumberg, P. S. & Aaronson, S. A. Molec. Cell. Biol. 7, 4146–4149 (1987).
Bodner, M. et al. Cell 55, 505–518 (1988).
Radler-Pohl, A., Pfeuffer, I., Karin, M. & Serfling, E. New Biol. 2, 566–573 (1990).
Harlow, E. & Lane, D. Antibodies, A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1988).
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Binétruy, B., Smeal, T. & Karin, M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351, 122–127 (1991). https://doi.org/10.1038/351122a0
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DOI: https://doi.org/10.1038/351122a0
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