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Swallowing dynein: a missing link in RNA localization?

Nature Cell Biology volume 2, pages E60–E62 (2000)Cite this article

Abstract

Localization of bicoid messenger RNA to the anterior cortex of the developing oocyte is essential for correct anterior-posterior patterning of the Drosophila embryo. It now seems that the Swallow protein functions as an adaptor, bridging bicoid mRNA to dynein, a molecular motor that would transport the complex anteriorly along microtubules.

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Figure 1: Asymmetric localization of bicoid mRNA in wild-type but not swa-mutant Drosophila oocytes.
Figure 2: Model for bicoid mRNA localization to the anterior cortex of the oocyte, based on the results of Schnorrer et al.5

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Authors and Affiliations

  1. Department of Genetics, the University of Minnesota, Cell and Developmental Biology, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, 55455, Minnesota, USA

    Tom Hays

  2. the CNRS Centre de Génétique Moléculaire, Ave de la Terrasse, Gif-sur-Yvette, 91198 , France

    Roger Karess

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  1. Tom Hays
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  2. Roger Karess
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Correspondence to Roger Karess.

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Hays, T., Karess, R. Swallowing dynein: a missing link in RNA localization? . Nat Cell Biol 2, E60–E62 (2000). https://doi.org/10.1038/35008687

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