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DNA defects target the centrosome

Nature Cell Biology volume 2, pages E28–E29 (2000)Cite this article

Abstract

When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to segregate chromosomes. These defects may result from the workings of a surveillance mechanism that acts to cull irreparable nuclei.

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Figure 1: The response of Drosophila syncytial nuclei to DNA defects.
Figure 2: Damaged or incompletely replicated DNA can arrest either the entry into mitosis or chromosome segregation during mitosis, depending on cell type.

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Authors and Affiliations

  1. Howard Hughes Medical Institute Predoctoral Fellow in the Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 , California, USA

    Smruti J. Vidwans

  2. the Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309 , Colorado, USA

    Tin Tin Su

Authors
  1. Smruti J. Vidwans
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  2. Tin Tin Su
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Vidwans, S., Su, T. DNA defects target the centrosome. Nat Cell Biol 2, E28–E29 (2000). https://doi.org/10.1038/35000099

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